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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
"Synapse elimination in botulinum toxin-paralysed rat muscles"
"Synapse elimination in botulinum toxin-paralysed rat muscles"
 
لغة الوثيقة : الانجليزية 
المستخلص : In order to determine the fate of the superfluous neuromuscular junctions (NMJs) formed during the course of botulinum toxin (BoTx)-induced paralysis, we have quantified the change in the total length of the nerve muscle contact area(s) following BoTx injection into rat calf muscles. The results indicate that: (1) at least some of the superfluous NMJs are eliminated following muscle recovery; (2) synapse elimination is a slow process, as 4 months after recovery it was not yet complete; (3) muscles with different content of type I and II fibers follow a different time course during synapse formation and elimination. We further investigated the possibility that the neural cell adhesion molecule (NCAM) would be the element whose loss from the NMJ might play a role in synapse elimination. Using immunofluorescence and immunoelectron microscopy we show that NCAM is exclusively localized between nerve terminals and Schwann cells and not between nerve terminals and muscle. This localization was maintained throughout paralysis and following recovery, suggesting that NCAM does not play a role in synapse elimination. 
ردمد : 16135345 
اسم الدورية : Journal of Neurology 
المجلد : 241 
العدد : 6 
سنة النشر : 1994 هـ
1994 م
 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, March 28, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
شريف حسنHassan, Sherif باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 26217.1 1 

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