Document Details

Document Type : Thesis 
Document Title :
Synthesis and biotransformations of some ring a and d substituted streoids by mucor plumbeus
الاصطناع والتحولات الحيوية لبعض الاسترويدات المستندلة في الحلقة A وD بواسطة الفطر موكوربلامبيوس
 
Subject : Chemistry 
Document Language : Arabic 
Abstract : The application of enzymes as reagents to bring about chemical reactions, is one of the fastest growing areas of research. The ability of enzymes to perform reactions under mild conditions, with a good regio- and stereospecificity, offers a valuable Potential for the production of chiral molecules in such diverse applications as synthesis of natural products, in medicinal chemistry and in the synthesis of drug metabolites. It is well known from the literature that the position and the stereochemistry of the substituents have an important role in the biotransformation results. In this work we will limit our studies to the effect of the position and stereochemistry of an epoxy group and nitrogen containing group ( hydrazone ) on the biotransformation results . The first chapter of the thesis provides a brief review of the literature concerning the microbiological hydroxylation of natural products using fungi cultures. The synthesis of the substrates the epoxy steroids and the steroidal hydrazones form the subject of chapter two. The biotransformation of the epoxy steroids along with steroidal hydrazones by Mucor Plumbeus are described in chapter three. The compounds were identified by spectroscopic methods. The 13C NMR spectra assignments of the compounds prepared during these studies are given in the appendix A. 
Supervisor : Dr. Khalid Omar Al-Footy 
Thesis Type : Master Thesis 
Publishing Year : 1428 AH
2007 AD 
Added Date : Monday, June 9, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إلهام عبدالرحيم سلمSlem, Ilham Abdul RahimResearcherMaster 

Files

File NameTypeDescription
 24320.pdf pdfالمستخلص
 24321.pdf pdfAbstract

Download This Page

Back To Researches Page