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Document Details
Document Type
:
Article In Journal
Document Title
:
"Synapse elimination in botulinum toxin-paralysed rat muscles"
"Synapse elimination in botulinum toxin-paralysed rat muscles"
Document Language
:
English
Abstract
:
In order to determine the fate of the superfluous neuromuscular junctions (NMJs) formed during the course of botulinum toxin (BoTx)-induced paralysis, we have quantified the change in the total length of the nerve muscle contact area(s) following BoTx injection into rat calf muscles. The results indicate that: (1) at least some of the superfluous NMJs are eliminated following muscle recovery; (2) synapse elimination is a slow process, as 4 months after recovery it was not yet complete; (3) muscles with different content of type I and II fibers follow a different time course during synapse formation and elimination. We further investigated the possibility that the neural cell adhesion molecule (NCAM) would be the element whose loss from the NMJ might play a role in synapse elimination. Using immunofluorescence and immunoelectron microscopy we show that NCAM is exclusively localized between nerve terminals and Schwann cells and not between nerve terminals and muscle. This localization was maintained throughout paralysis and following recovery, suggesting that NCAM does not play a role in synapse elimination.
ISSN
:
16135345
Journal Name
:
Journal of Neurology
Volume
:
241
Issue Number
:
6
Publishing Year
:
1994 AH
1994 AD
Article Type
:
Article
Added Date
:
Sunday, March 28, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
شريف حسن
Hassan, Sherif
Researcher
Doctorate
Files
File Name
Type
Description
26217.1
1
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