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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Anti-TNF {alpha} antibody infliximab treatment for an infant with fistulising Crohn's disease.
Anti-TNF {alpha} antibody infliximab treatment for an infant with fistulising Crohn's disease.
Document Language
:
English
Abstract
:
A female infant presented at the age of 4 weeks with dyschezia and bloody streaking of stools which did not improve on elemental formula for proposed cow’s milk protein allergy. At 6 months of age perianal ulceration appeared which evolved into multiple fistulas opening into the perineum. A diagnosis of infantile Crohn’s disease was made after colonoscopy and histopathology examination and exclusion of other conditions. An 8 week trial of total parenteral nutrition, in addition to corticosteroids, salazopyrine, metronidazole, and azathioprine failed to arrest deterioration of the perianal fistulas. Treatment with the anti-TNFα antibody infliximab was started at 5 mg/kg/dose at 9 months of age. She was given three doses at 0, 2, and 6 weeks, respectively. This resulted in significant healing of her fistulas and cessation of fistula output. This improvement was sustained at the time of last follow-up 10 months after treatment.
ISSN
:
4522111
Journal Name
:
BMJ Case Reports
Volume
:
3
Issue Number
:
1
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Thursday, November 18, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عمر سعادة
Saadah, Omar I
Researcher
Doctorate
saadaho@hotmail.com
Files
File Name
Type
Description
27956.pdf
pdf
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