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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Comparison of the fluorescence polarization immunoassay and the microbiological assay methods for the determination of gentamicin concentration in human serum
Comparison of the fluorescence polarization immunoassay and the microbiological assay methods for the determination of gentamicin concentration in human serum
Subject
:
Pharmacology
Document Language
:
English
Abstract
:
The performance of the fluorescence polarization immunoassay (FPIA) was compared with that of a microbiological assay for the measurement of serum gentamicin concentrations. Within-run precision from duplicate assays of two concentrations (4 and 8 micrograms/ml) using FPIA and the microbiological assay yielded coefficients of variation (r) of 2.62%, 1.76% (n = 12) and 8.06%, 6.87% (n = 12), respectively. Day-to-day precision was estimated by repetitive analysis of 4 and 8 micrograms/ml control samples over a 3-week period. Coefficients of variation (r) were 2.57%, 3.09% (n = 8) and 10.71%, 14.20% (n = 8) for FPIA and the microbiological assay, respectively. Linear regression analysis performed on data from parallel determinations on 143 patient samples by the two methods showed correlations in the order of 0.74. The FPIA offers a rapid, efficient, and accurate system for therapeutic monitoring of gentamicin serum levels
ISSN
:
1536-3694
Journal Name
:
Therapeutic Drug Monitoring
Volume
:
8
Issue Number
:
2
Publishing Year
:
1416 AH
1986 AD
Article Type
:
Article
Added Date
:
Thursday, March 31, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أسامة طيب
Tayeb, Osama
Investigator
Doctorate
سميرة اسلام
Islam, Samira
Researcher
Doctorate
Files
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Type
Description
29430.pdf
pdf
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