Main Page
Faculty Deanship
Dean
Health Empowerment Unit
Strategic Planning Unit
Development and Quality Unit
Medical and Bioethics Unit
Vice Dean for Graduate Studies and Research
Vice Dean for Female Section
Vice dean for Academic Affairs
Examination and Assessment Unit
Internship and Alumni Unit
Student Research Unit
E-learning Unit
Student Mentoring and Support Unit
Community Service Unit
Talent and Creativity Care Unit
Continuing Education Unit
Neuroscience Research Unit
Vice Deanship of Clinical Affairs / Administration
Organizational Structure
Departments
Basic Sciences
Department of Anatomy
Department of Pharmacology
Department of Pathology
Department of Microbiology and Medical Parasitolog
Deparment of Clinical Biochemistry
Department of Physiology
Department of Medical Genetics
Clinical Sciences
Department of Otorhinolaryngology
Department of Obstetrics and Gynecology
Department of Hematology
Department of Medical Education
Department of Anesthesia
Department of Family Medicine
Department of Community Medicine
Department of Surgery
Department of Orthopedic Surgery
Department of ophthalmology
Department of Radiology
Department of Internal Medicine
Department of Pediatrics
Department of Emergency Medicine
Department of Urology
Department of Dermatology
Latest News
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Brachytherapy Boost in the Neoadjuvant Radiation Therapy for Locally Advanced Rectal Cancer at King Abdulaziz University Hospital
Brachytherapy Boost in the Neoadjuvant Radiation Therapy for Locally Advanced Rectal Cancer at King Abdulaziz University Hospital
Subject
:
Radiation Therapy
Document Language
:
English
Abstract
:
The aim is to evaluate the pathological complete response and toxicity when using brachytherapy boost as part of the preoperative chemoradiation therapy in patients with rectal cancer. A retrospective review of all patients with rectal cancer treated at King Abdulaziz University Hospital. Fifty-five patients had neoadjuvat radiotherapy 45 Gy in 25 fractions of external beam radiation as Phase I of radiotherapy followed by external beam boost: 540 cGy/3 fractions in 31 patients or Ir192 HDR brachytherapy boost in 17 patients. The pathological response rate, toxicity profile, overall survival and disease free survival was compared between different radiation therapies modalities. The pathological response rate was complete in 14 (25.5%) patients, partial (PR) in 29 (52.7%) patients, unknown (did not do surgery) in 9 (16.5%) patients and stable disease in 3 (5.4%) patients. In brachytherapy boost, pathological complete response was 47% vs. 18% external beam boost (p = 0.004). Toxicity profile was better in the brachytherapy group. Overall survival was 93% and the disease free survival was 60% which were not influenced by the modality of radiation therapy used. High Dose Rate Brachytherapy boost result in a higher pathological response rate without increase in side effect as compared to the external beam radiation boost in the neoadjuvant radiation therapy for locally advanced rectal cancer
ISSN
:
1319-1004
Journal Name
:
Medical Science Journal
Volume
:
16
Issue Number
:
1
Publishing Year
:
1430 AH
2009 AD
Article Type
:
Article
Added Date
:
Monday, July 25, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ياسر بهادر
Bahadur, Yasir
Researcher
Doctorate
Files
File Name
Type
Description
29978.pdf
pdf
Back To Researches Page