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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
3D Anatomy-Based Planning Optimization For HDR Brachytherapy of Cervix Cancer
3D Anatomy-Based Planning Optimization For HDR Brachytherapy of Cervix Cancer
Subject
:
Radiation Therapy
Document Language
:
English
Abstract
:
Aim: To evaluate the dosimetric superiority of inverse planning optimization and isodose line manually optimization (both 3D planning methods) versus conventional treatment plan (point A planning method), using various dosimetric indices in HDR brachytherapy planning for cervical carcinoma. Methods and materials: The data from 10 patients treated with HDR brachytherapy for cervical cancer using tandem and ovoids has been analyzed. Target and organ at risk volumes were defined using systematic guidelines. Dose distributions were created according to three different dose calculation protocols: point A, isodose line manually optimization, and inverse planning and dose–volume histograms from these plans were analyzed, and all plans were evaluated for V100%, V95%, the conformity index CI = V100%/VCTV, and the dose homogeneity index DHI = (V100% - V150%)/ V100% for target. For rectum D5cc, V50%, V70% and V100% of prescription dose were evaluated. For bladder D5cc, V50%, V80% and V100% of prescription dose were evaluated. Results: Both 3D planning methods showed significant better target coverage compared with point A calculation: average 85.65% isodose manually shaping vs. 48.43% point A calculation (p < 0.003) and 90.33% inverse planning vs. 48.43% point A calculation (p < 0.001) for V7Gy. Dose homogeneity was better for both 3D planning protocols: average 0.33% isodose manually shaping vs. 0.39% point A calculation (p < 0.008) and 0.31% inverse planning vs. 0.39% point A calculation (p < 0.031) for DHI. For organs at risk, point A calculation average was 4.29 Gy vs. 4.99 Gy isodose manually shaping (p < 0.037) and 4.29 Gy point A calculation vs. 5.14 Gy inverse planning (p < 0.013) for D5cc of rectum; and average 4.88 Gy point A calculation vs. 6.32 Gy isodose manually shaping (p < 0.019) and 4.88 Gy point A calculation vs. 5.78 Gy inverse planning (p < 0.019) for D5cc of bladder. Conclusion: The 3D planning methods improve dose conformity and homogeneity of target coverage while minimizing dose to critical structures by chosen the appropriate priorities and allows for easy comparison between patients
ISSN
:
0000-0000
Journal Name
:
Saudi Journal of Obstetrics and Gynecology
Volume
:
11
Issue Number
:
2
Publishing Year
:
1430 AH
2009 AD
Article Type
:
Article
Added Date
:
Friday, July 29, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ياسر بهادر
Bahadur, Yasir
Investigator
Doctorate
yasirbahadur@hotmail.com
Files
File Name
Type
Description
29986.pdf
pdf
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