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Document Details
Document Type
:
Article In Journal
Document Title
:
The transport of glutamine and alanine into rat colonocytes
The transport of glutamine and alanine into rat colonocytes
Subject
:
Biochemistry
Document Language
:
English
Abstract
:
The transport of glutamine and alanine into isolated rat colonocytes was studied. The transport of both amino acids appears to be dependent on a Na+ gradient. The apparent Km values for the transport of glutamine and alanine were 2.56 +/- 0.84 and 5.35 +/- 1.20 mM respectively, but with similar Vmax. values. Glutamine and alanine transport were mutually competitive, and the transport of both amino acids was competitively inhibited by 2-methylaminoisobutyrate. In contrast, histidine inhibited the transport of both glutamine and alanine non-competitively. It is concluded that glutamine and alanine are transported into rat colonocytes by a common carrier system similar to System A of other cells. It is suggested that the metabolic function of this transport system in rat colonocytes might be the partial exchange of extracellular glutamine for intracellular alanine
ISSN
:
0264-6021
Journal Name
:
The Biochemical Journal
Volume
:
238
Issue Number
:
1
Publishing Year
:
1406 AH
1986 AD
Article Type
:
Article
Added Date
:
Monday, November 28, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد العرضاوي
Ardawi, Mohammed
Researcher
Doctorate
Files
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Type
Description
31397.pdf
pdf
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