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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Comparison of Three Commercial Assays for the Determination of Serum C-Reactive Protein
Comparison of Three Commercial Assays for the Determination of Serum C-Reactive Protein
Subject
:
Internal Medicine
Document Language
:
English
Abstract
:
C-reactive protein (CRP) is me of the acute phase reactants produced by hepatocytes feflowing trauma. Serial measurenient of strum CRP is reported to be valuable in monitoring patients .dmiUed to the intensive care unit (ICU). This report compasd the use & three commercial assays for the routine determination of serum CRP. Two of the assays were quantitative (Tina-Quant (TQ) and Abbott TDx) whereas the other assay was saniquantitative (Mercia latex agglutination). The effect of lipaemia a) the measusument of CRP by immunoturbidimetsy was also examined. Serial serum samples (n=97) from 13 patients admitted to the ICU with multiple fractures (n=7) myocardial infarction (n4), hepatorenal failure (n=1), haernatemesis (n=2), and pancreatitis (n1) were analyzed for CRP concentrations. Good correlation (r2=0.96) was obtained between the TQ and TDx assays in contrast to that obtained with Mercia (?=0.56 and 0.34, respectively). TQ assay gave significantly (P-cO.005) lower CRP results than that of 1’Dx. Lipaanis resulted in ambiguous CR1’ resuks by irnmunotuthidimeuy, the effect being due to optical interference rather than to lipid micefles binding to CR1’ molecules. In conclusion, tbe Mercia method was labor-intensive and time-consuming, whereas the TQ and TDx assays were fast and easy to perfonn; however, in contrast to Mercia, required dedicated expensive equipment. Interference by lipaemia was eliminates! by serially diluting the sample or by ultracentrifugation. Determination of CR1’ in serial samples fran intensive care patients was useful in early detection of sepsis
ISSN
:
1319-1004
Journal Name
:
Medical Science Journal
Volume
:
7
Issue Number
:
2
Publishing Year
:
1419 AH
1999 AD
Article Type
:
Article
Added Date
:
Friday, April 20, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
طريف زواوي
Zawawi, Tarif
Investigator
Doctorate
Files
File Name
Type
Description
32920.pdf
pdf
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