Document Details

Document Type : Article In Journal 
Document Title :
Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects
الأكسجين عالي الضغط يسبب زيادة في عامل نمو بطانة الاوعية الدموية (VEGF) في العيوب ذات الحجم الحرج.
 
Subject : Oral and Maxillofacial Surgery 
Document Language : English 
Abstract : Background: Hyperbaric oxygen therapy (HBO) promotes osseous healing, however the mechanism by which this occurs has not been elucidated. HBO may promote angiogenesis, which is vital for bone healing. Vascular endothelial growth factor (VEGF) is one of the key factors that stimulates angiogenesis. Objective. The objective of this study was to investigate whether HBO altered VEGF expression during bone healing. Methods and materials: Archived samples from calvarial defects of rabbits exposed to HBO (2.4 ATA, 90 minutes a day, 5 days a week for 4 weeks) and normobaric oxygen controls (NBO) were analyzed by immunohistochemistry. Results: VEGF expression in 6-week HBO samples was elevated compared to NBO (P  .012). Staining of the 12week HBO samples was reduced compared to 6-week HBO (P = .008) and was similar to 6- and 12-week NBO control samples. Conclusion: HBO therapy resulted in increased VEGF expression in the defects even 2 weeks after the termination of treatment (6 weeks postsurgery) 
ISSN : 1079-2104 
Journal Name : Oral Surgery Oral Medicien Oral Pathology Oral Radiology Endodontics 
Volume : 105 
Issue Number : 0 
Publishing Year : 1429 AH
2008 AD 
Article Type : Article 
Added Date : Sunday, August 12, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أحمد محمد سعيد جانJan, Ahmed Mohammed SaeedResearcherDoctorateamjan@kau.edu.sa

Files

File NameTypeDescription
 34105.pdf pdfAhmed Jan VEGF OOOOE 2008

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