Document Details

Document Type : Thesis 
Document Title :
Assessment of Marine Sponge – Derived Fungi for Biological Activities
تقييم الفعالية البيولوجية للفطريات المعزولة من الاسفنجيات البحرية
 
Subject : Faculty of Pharmacy - Natural Prodoucts And Alternative Medicine 
Document Language : Arabic 
Abstract : The main aim of this dissertation is the exploration of symbiotic fungi derived from Red Sea sponges as a source of bioactive compounds. The fungus Penicillium vinaceum isolated from the Red Sea sponge Hyrtios erecta was cultivated using liquid cultures. Fungal mycelia were separated from culture media and left in MeOH overnight for extraction. Different chromatographic techniques were used for isolation. This included column chromatography (packed with silica or Sephadex) and high performance liquid chromatography. Finally, seven pure compounds were isolated. The structures of the isolated compounds were established based on different spectroscopic data including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, HSQC, and HMBC). On reviewing the literature, one alkaloid derived from diketopiperazine moiety was found to be new, isolated for the first time from a natural source. In addition, six known compounds including two diketopiperazine alkaloids, two indole alkaloids, an isocoumarin derivative and terretrione A were isolated and identified. All the isolated compounds were evaluated for their antimicrobial and cytotoxic activities. Key Words: Hyrtios erecta, Penicillium vinaceum, HPLC, NMR, antimicrobial activity, Cytotoxic activity. 
Supervisor : Prof. Dr. Diaa Tohamy Ali Youssef 
Thesis Type : Master Thesis 
Publishing Year : 1436 AH
2015 AD 
Added Date : Monday, May 4, 2015 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إبراهيم الحسين عسيريAsiri, Ibrahim AL-HossainResearcherMaster 

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