Document Details Document Type : Article In Journal  Document Title : Acylated pregnane glycosides from Caralluma quadrangula Acylated pregnane glycosides from Caralluma quadrangula   Document Language : English  Abstract : In a previous study, the methanolic extract as well as the chloroform fraction of the aerial parts of Caralluma quadrangula (Forssk.) N.E.Br. indigenous to Saudi Arabia showed significant in vitro cytotoxic activity against breast cancer (MCF7) cell line. In a biologically-guided fractionation approach, four acylated pregnane glycosides were isolated from the chloroform fraction of C. quadrangula. The structures of the isolated compounds were elucidated by the analysis of their MS and NMR data. The compounds were identified as 12,20-di-O-benzoylboucerin 3-O-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (1), 12,20-di-O-benzoylboucerin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), 12,20-di-O-benzoylboucerin 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (3) and 12,20-di-O-benzoyl-3 beta,5 alpha,12 beta,14 beta,20-pentahydroxy-(20R)-pregn-6-ene 3-0-beta-D-glucopyranosyl-(1 -> 4)-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (4). The isolated compounds were tested for their cytotoxic activity against breast cancer (MCF7) cell line  ISSN : 0031-9422  Journal Name : PHYTOCHEMISTRY  Volume : 88  Issue Number : 1  Publishing Year : 1434 AH 2013 AD  Article Type : Article  Added Date : Wednesday, July 26, 2017  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email Hossam Abdallah Abdallah, Hossam Researcher     Abdel-Moneim Osman Osman, Abdel-Moneim Researcher     Hussein Almehdar Almehdar, Hussein Researcher     Essam Abdel-Sattar Abdel-Sattar, Essam Researcher     Files File Name Type Description  42275.pdf pdf   Back To Researches Page