Document Details

Document Type : Thesis 
Document Title :
) Neurophysiological study on possible protective and therapeutic effect of Sidr ( Zizyphus Spina-christi ) leaves and fruits extract in male albino rat
دراسة فسيولوجية عصبية على التأثير الوقائي والعلاجي المحتمل لمستخلص أوراق وثمار السدر في ذكور الجرذان المعاملة بالبنتيلين تترازول
 
Subject : ) Neurophysiological study on possible protective and therapeutic effect of Sidr ( Zizyphus Spina-christi ) leaves and fruits extract in male albino rat 
Document Language : Arabic 
Abstract : Sidr is one of the most common medicinal plants frequently used in folk medicine , especially in Saudi Arabia . This study aims basically to identify influence of daily treatment by Sidr Leaves and Fruits Extract in total content of neurotransmitters (norepinephrine , dopamine, serotonin and gammaaminobutyric acid ) in different brain regions : (Cerebellum - brainstem - cerebral cortex – hypothalamus and hippocampus ) in male albino rat , in addition to know the role of possible protective and therapeutic of Sidr leaves and fruits extract against convulsions caused by substance pentylenetetrazol. Chronic injection by leaves extract (50 mg/kg i.p.) and a gradual withdrawal increasing neurotransmitters content in most different brain regions at most of time interval , this is probably due to the presence of cyclic peptides and peptides alkaloids in the extract which worked on the inhibition of Ca2+/ calmodulin protein binding which plays an important role in release of these neurotransmitters , on the other hand saponin discourage monoamines release from secretary of cells that produce them , so the content is increased. The study also showed that Chronic injection by fruits extract (50 mg/kg i.p.) and a gradual withdrawal decreasing neurotransmitters content in most different brain regions at most of time interval , which could be due to the presence of ascorbic acid which caused neurotransmitter release from presynaptic by enhanced Ca2+ influx , also ascorbic acid increase nitric oxide (NO) levels , so the content of neurotransmitter is decreased . The results also showed a clear improvement in the total content of neurotransmitters in treated animals by protective and therapeutic dose of Sidr leaves and fruits extract which decreased significantly by treatment with pentylenetetrazol , this is probably due to sidr leaves are rich material saponin that worked to inhibit the release neurotransmitters of cells that produce them which has been activated with pentylenetetrazol , also , the sidr fruits rich in ascorbic acid, which work to discourage the activity of the Na, K-ATPase leading to inhibition of nerve conduction and then inhibition of neurotransmitter release and increased content in the brain. The study concludes that leaves and fruits extract may have protective and therapeutic role as anticonvulsant effect , this needs to be further research and study . 
Supervisor : Dr. Abeer Muhammad Saad Waggas 
Thesis Type : Master Thesis 
Publishing Year : 1431 AH
2010 AD 
Number Of Pages : 172 
Added Date : Tuesday, June 22, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ريم حسب الله الحسنيAl-hasani, Reem HasaballahInvestigatorMasterRhh_81@hotmail.com

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